Professional Title/Position: Professor, Vice dean (presiding) of College of Animal Sciences
Educational Background:
2009-2014 Ph.D., Biochemistry and Molecular Biology, Institute of Microbiology, Chinese Academy of Sciences
2006-2009 Master of Agriculture, Preventive Veterinary Medicine, Shandong Agricultural University
2002-2006 Bachelor of Agriculture, Veterinary Medicine, Shandong Agricultural University
Research Direction:
1.Pathogenic mechanism of viruses such as influenza virus
2.Viral infection and host immune response
3.Molecular mechanisms of host-pathogen interactions
4.Viral infection and DNA damage response
5.Viral infection and protein post-translational modifications
Study Abroad Experience:
2017-2021 Postdoc., Department of Oncology, Mayo Clinic, Rochester, MN, USA
Representative Works:
1.Guijie Guo#, Ming Gao#, Xiaochen Gao, Bibo Zhu, Min Deng, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng*, and Zhenkun Lou*. Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling. Nature Communications 12(1):2187 (2021). (#First author, *Corresponding author)
2.Guijie Guo#, Ming Gao#, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Kuntian Luo, Yong Zhang, Jie Sun, Min Deng, and Zhenkun Lou*. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduction and Targeted Therapy 6(1):119 (2021).
3.Biao Chen#, Guijie Guo#, Guoqing Wang#, Qianwen Zhu, Lulu Wang, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang, and Ji-Long Chen*. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus. PLOS Pathogens 20(1):e1011958 (2024).
4.Ming Gao#, Guijie Guo#, Jinzhou Huang, Xiaonan Hou, Hyoungjun Ham, Wootae Kim, Fei Zhao, Min Deng, Xinyi Tu, Qin Zhou, Chao Zhang, Qian Zhu, Jiaqi Liu, Yuanliang Yan, Zhijie Xu, Ping Yin, Kuntian Luo, John Weroha, Min Deng*, Daniel D. Billadeau*, and Zhenkun Lou*. DOCK7 protects against replication stress by promoting RPA stability on chromatin. Nucleic Acids Research 49(6):3322-3337 (2021).
5.Ming Gao#, Guijie Guo#, Jinzhou Huang, Jake A Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, and Zhenkun Lou*. USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP. Nature Communications 11(1):5362 (2020).
List of Research Projects:
1.Animal virus and host immune response. National Natural Science Foundation of China, National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas), Principal Investigator, 2022.01-2024.12;
2.Function and molecular mechanism of the DNA damage response in the interaction between influenza A virus and host. National Natural Science Foundation of China, General Program, Principal Investigator, 2024.01-2027.12.
Email:guoguijie@fafu.edu.cn